Xi'an Quanao Biotech Co., Ltd.
$60.61-4 Kilogram
$58.95-24 Kilogram
$55.825-99 Kilogram
$49.8≥100Kilogram
| Jenis bayaran: | D/A,T/T,D/P,Paypal,Others |
| Incoterm: | FOB,CIF,EXW,DAF,DES |
| Pengangkutan: | Ocean,Land,Air,Express,Others |
| Port: | Shanghai |
Model No.: Azelaic Acid
Jenama: QA
CAS NO.: 123-99-9
Other Names: Azelainic Acid, Nonanedioic Acid
MF: C9h16o4
EINECS No.: 204-669-1
Province: Shaanxi
Origin: China
Brand Name: Qa
Model NO.: Qa
Purity: 99%min, 99%
Nama produk: Azelaic Acid Powder
Appearance: White Powder
CAS: 123-99-9
Permohonan: Cosmetic Ingredient
EINECS No: 204-669-1
Place Of Origin: Shaanxi, China
Mesh: 100% Pass 80 Mesh
| Unit Jualan | : | Kilogram |
| Jenis Pakej | : | dibungkus dalam: 1kg dengan bekas plastik berganda di dalam/Beg kerajang aluminium di luar. 25kg dengan bekas plastik berganda di dalam/Drum gentian di luar. |
| Contoh Gambar | : |
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Ramuan Rawatan Kulit Asid Azelaic ialah Ramuan Penjagaan Dermatosis dan ubat rawatan, terutamanya digunakan untuk rawatan jerawat, chloasma dan pemendapan melanin kulit. boleh uesd Bahan Farmaseutikal Aktif, Bahan Penjagaan Kulit Sensitif , juga menggunakan Bahan Mentah Kosmetik , Bahan kimia harian dan sebagainya.
Bahan Penjagaan Dermatosis Gred Kosmetik Asid Azelaik 99% Harga Asid Azelaik, Asid Nonanedioik
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Product Name
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Azelaic Acid
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Synonym
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Nonanedioic acid
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Molecular Formula
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C9H16O4
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Molecular Weight
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188.22
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Description
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Azelaic acid is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects. In vitro, azelaic acid hasbeen shown to inhibit DNA polymerases in several tumor cell lines.
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Chemical Properties
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Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. This saturated dicarboxylic acid exists as a white powder. It is found in wheat, rye, and barley. It is a component of a number of hair and skin conditioners.
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Chemical Properties
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white to cream solid
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Chemical Properties
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Nonanedioic acid is the best known dicarboxylic acid. Its name stems from the action of nitric acid (azote, nitrogen, or azotic,
nitric) oxidation of oleic or elaidic acid. It was detected among products of rancid fats. Its origin explains for its presence in
poorly preserved samples of linseed oil and in specimens of ointment removed from Egyptian tombs 5000 years old. Azelaic acid was prepared by oxidation of oleic acid with potassium permanganate, but now by oxidative cleavage of oleic acid with chromic acid or
by ozonolysis. Azelaic acid is used, as simple esters or branched-chain esters) in the manufacture of plasticizers (for vinyl
chloride resins, rubber), lubricants and greases. Azelaic acid is now used in cosmetics (treatment of acne). It displays
bacteriostatic and bactericidal properties against a variety of aerobic and anaerobic micro-organisms present on acne-bearing
skin. Azelaic acid was identified as a molecule that accumulated at elevated levels in some parts of plants and was shown to be
able to enhance the resistance of plants to infections.
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Uses
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antiacne, antiproliferative agent
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Uses
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antifungal, binds to membrane sterols
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Production Methods
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Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic acid. It is produced naturally
by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic
acid gives azelaic acid.
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Application
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Polymers and related materials
Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine azelaic acid forms
Nylon - 6,9, which finds specialized uses as a plastic.
Medical
Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne . It belongs to a class of
medication called dicarboxylic acids. It works by killing acne bacteria that infect skin pores. It also decreases the production
of keratin, which is a natural substance that promotes the growth of acne bacteria Azelaic acid is also used as a topical gel
treatment for rosacea, due to its ability to reduce inflammation . It clears the bumps and swelling caused by Rosacea. Azelaic
acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyper pigmentation , particularly in
those with darker skin types. It has been recommended as an alternative to hydroquinone (HQ). As a tyrosinase inhibitor, azelaic
acid reduces synthesis of melanin.
Brand names
AzClear Action ( 20 % lotion, Ego Pharmaceuticals), Azelex (20% cream, Allergan), White Action cream (20 % cream ,2 % glycolic
acid), SynCare), Finacea (15 % gel, Intendis/Berlex Laboratories, subsidiaries of Bayer AG), Finevin (20 % cream, Intendis /
Berlex Laboratories), Skinoren (20 % cream or 15% gel, Intendis), Melazepam, Strata Dermatologics, 2oz, Mixed Dicarboxylic Acids
20 % Azelaic Acid Cream.,and Azaclear (azelaic acid and niacinamide, Epikinetics LLC). .
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Indications
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Azelaic acid (Azelex) is a naturally occurring dicarboxylic acid produced by the yeast Malassezia furfur. Azelaic acid inhibits
tyrosinase, a rate-limiting enzyme in the synthesis of the pigment melanin. This may explain why diminution of melanin pigmentation occurs in the skin of some patients with pityriasis versicolor, a disease caused by M. furfur. Azelaic acid is bacteriostatic against a number of species thought to participate in the pathogenesis of acne, including Propionibacterium acnes. The drug may also reduce microcomedo formation by promoting normalization of epidermal keratinocytes. |
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Biotechnological Applications
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In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection. It serves as a signal that
induces the accumulation of salicylic acid, an important component of a plant's defensive response. |
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Clinical Use
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Azelaic acid is used for the treatment of mild to moderate acne, particularly in cases characterized by marked
inflammation-associated hyperpigmentation |
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